蔡三軍 教授 教授，博士生導師 E-mail: caisanjuncsj@163.com

　　復旦大學附屬腫瘤醫院大腸癌多學科協作組首席專家、復旦大學大腸癌診治中心主任、上海市抗癌協會大腸癌專業委員會主任委員、中國抗癌協會大腸癌專業委員會前主任委員、美國臨床腫瘤指南(NCCN)中國版專家委員會委員、NCCN大腸癌臨床實踐指南（中國版）外科執筆人、主要從事結直腸癌基礎和臨床研究，尤其擅長于大腸癌的手術治療，是中國著名的大腸癌專家。 

      主編《結直腸肛門腫瘤》（北京大學出版社，2005）及《循證結直腸肛管腫瘤學》（上海科學技術出版社2015）。主持國家自然科學基金課題、國家863及973、復旦211等重大科研課題，累計經費4200余萬。

      近5年發表醫學論文90余篇，其中SCI 70余篇。2012獲得上海市科學技術及教育部科技進步二等獎，2018獲上海預防醫學會科學技術二等獎，2019獲第三屆國之名醫盛典-卓越建樹獎和科教資訊一等獎。

研究領域：

1、大腸癌、胃癌、軟組織腹膜后腫瘤、惡性黑色素瘤等腹部腫瘤的手術治療；
2、局部晚期大腸癌及復發轉移性大腸癌的綜合治療；
3、大腸癌的早期篩查、分子生物標志物及復發轉移機制研究；
4、大腸癌類器官平臺建設與轉化治療。

研究團隊：

　自2005年來擔任復旦大學大腸癌中心主委、腫瘤醫院大腸癌多學科協作組首席科學家，對大腸癌診治方面的各種治療方式、綜合治療、個體化治療有較深的理解，形成了國內最好的大腸癌MDT隊伍，團隊包括大腸外科、放療科、腫瘤內科、病理科、放射診斷、內鏡科、肝外科、介入科及中醫科，積極推動了國內大腸癌的規范性多學科綜合治療的發展。

代表性論著：

1. Li Q^#, Wei P^#, Wu J, Zhang M, Li G, Li Y, Xu Y, Li X, Xie D, Cai S^*, Xie K^*, Li D^*. The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect. Oncogene, 2019Jan; 38(4):483-496.
2. Hu X^#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ^*. Adjuvant Chemotherapy Seemed Not to Have Survival Benefit in Rectal Cancer Patients with ypTis-2N0 After Preoperative Radiotherapy and Surgery from a Population-Based Propensity Score Analysis. Oncologist, 2019 Jun; 24(6):803-811.
3. Li Y^#, Wang R^#, Huang D^#, Ma X, Mo S, Guo Q, Fu G, Li Y, Xu X, Hu X, Zhou Y, Deng Y, Zhang L, Chen H, Gao J, Zhang Z, Cai S^*, Hua G^*, Peng J^*. A novel human colon signet-ring cell carcinoma organoid line: establishment, characterization and application. Carcinogenesis, 2019 Nov 19.
4. Zhang S^#, Yang Y, Weng W, Guo B, Cai G, Ma Y, Cai S^*. Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer. J Exp Clin Cancer Res, 2019 Jan 10; 38(1):14.
5. Hu X^#, Li YQ, Ma XJ, Zhang L, Cai SJ^*, Peng JJ^*. A Risk Signature With Inflammatory and T Immune Cells Infiltration in Colorectal Cancer Predicting Distant Metastases and Efficiency of Chemotherapy. Front Oncol, 2019 Aug 13; 9:704.
6. Feng Y^#, Li Y, Huang D, Cai S^*, Peng J^*. HER2 as a potential biomarker guiding adjuvant chemotherapy in stage II colorectal cancer. Eur J Surg Oncol, 2019 Feb; 45(2):167-173.
7. Hu X^#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ^*. Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway. J Exp Clin Cancer Res, 2018 Mar 2; 37(1):41.
8. Li Q^#, Li Y^#, Li J, Ma Y, Dai W, Mo S, Xu Y, Li X^*, Cai S^*. FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1alpha/CEACAM5 functional axis. Int J Biol Sci,  2018 May 12; 14(7):726-735.
9. Hu X^#, Li YQ, Li QG, Ma YL, Peng JJ^*, Cai SJ^*. Baseline Peripheral Blood Leukocytosis Is Negatively Correlated With T-Cell Infiltration Predicting Worse Outcome in Colorectal Cancers. Front Immunol, 2018 Oct 12; 9:2354.
10. Hu X^#, Li YQ, Li QG, Ma YL, Peng JJ^*, Cai SJ^*. ITGAE Defines CD8+ Tumor-Infiltrating Lymphocytes Predicting a better Prognostic Survival in Colorectal Cancer. EBioMedicine, 2018 Sep; 35:178-188.
11. Hu X^#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ^*. Osteoglycin-induced VEGF Inhibition Enhances T Lymphocytes Infiltrating in Colorectal Cancer. EBioMedicine, 2018 Aug; 34:35-45.
12. Li Q^#, Dai W^#, Jia H^#, Li Y, Xu Y, Li X^*, Cai G^*, Cai S^*. Prognostic Impact of Hypochloremia in Patients With Stage I to III Colorectal Cancer After Radical Resection. Dis Colon Rectum, 2018 Nov; 61(11):1273-1280.
13. Li Y^#, Feng Y^#, Dai W, Li Q, Cai S^*, Peng J^*. Prognostic Effect of Tumor Sidedness in Colorectal Cancer: A SEER-Based Analysis. Clin Colorectal Cancer, 2019 Mar; 18(1):e104-e116.
14. Yang Y^#, Weng W^#, Peng J^#, Hong L^#, Yang L, Toiyama Y, Gao R, Liu M, Yin M, Pan C, Li H, Guo B, Zhu Q, Wei Q, Moyer MP, Wang P, Cai S^*, Goel A^*, Qin H^*, Ma Y^*. Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-kappaB, and Up-regulating Expression of MicroRNA-21. Gastroenterology, 2017 Mar; 152(4):851-866.
15. Shi D^#, Liang L^#, Zheng H, Cai G, Li X, Xu Y^*, Cai S^*. Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion in colorectal cancer. Biomed Pharmacother, 2017 Jan; 85:355-361.
16. Li Y^#, Liang L^#, Dai W, Cai G, Xu Y, Li X, Li Q^*, Cai S^*. Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer. Mol Cancer, 2016 Aug 24; 15(1):55.
17. Wang S^#, Zhang Q^#, Yang P, Yu X, Huang LY, Shen S^*, Cai S^*. Manganese Oxide-Coated Carbon Nanotubes As Dual-Modality Lymph Mapping Agents for Photothermal Therapy of Tumor Metastasis. ACS Applied Materials & Interfaces, 2016 Feb 17; 8(6):3736-43.
18. Li Y^#, Jia H^#, Yu W, Xu Y, Li X, Li Q^*, Cai S^*. Nomograms for predicting prognostic value of inflammatory biomarkers in colorectal cancer patients after radical resection. Int J Cancer, 2016 Jul 1; 139(1):220-31.
19. Li Q^#, Wei P^#, Huang B^#, Xu Y, Li X, Li Y, Cai S^*, Li D^*. MAEL expression links epithelial-mesenchymal transition and stem cell properties in colorectal cancer. Int J Cancer, 2016; 139:2502-11.
20. Li Q^#, Qin Y^#, Wei P, Lian P, Li Y, Xu Y, Li X, Li D^*, Cai S^*. Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma. Mol Cancer Res, 2016 Sep; 14(9):830-40.
21. Li X^#, Liang L^#, Huang L, Ma X, Li D, Cai S^*. High expression of protein phosphatase 4 is associated with the aggressive malignant behavior of colorectal carcinoma. Mol Cancer, 2015 Apr 28; 14:95.
22. Li Q^#, Meng X^#, Liang L, Xu Y, Cai G^*, Cai S^*. High preoperative serum globulin in rectal cancer treated with neoadjunctive chemoradiation therapy is a risk factor for poor outcome. Am J Cancer Res, 2015 Aug 15; 5(9):2856-64.
23. Li Q^#, Wu J^#, Wei P, Xu Y, Zhuo C, Wang Y, Li D, Cai S^*. Overexpression of forkhead Box C2 promotes tumor metastasis and indicates poor prognosis in colon cancer via regulating epithelial-mesenchymal transition. Am J Cancer Res, 2015 May 15; 5(6):2022-34.
24. Zhuo C^#, Li Z, Xu Y, Wang Y, Li Q, Peng J, Zheng H, Wu P, Li B^*, Cai S^*. Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival. Molecular Cancer, 2014 Jun 18; 13:153.
25. Xu Y^#, Xu Q^#, Yang L, Ye X, Liu F, Wu F, Ni S, Tan C, Cai G, Meng X, Cai S^*, Du X^*. Identification and validation of a blood-based 18-gene expression signature in colorectal cancer. Clin Cancer Res, 2013 Jun 1; 19(11):3039-49.
26. Peng J^#, Chen W, Venook AP, Sheng W, Xu Y, Guan Z, Cai G, Cai S^*. Long-term outcome of early-stage rectal cancer undergoing standard resection and local excision. Clin Colorectal Cancer , 2011 Mar 1; 10(1):37-41.