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復旦大學附屬腫瘤醫院大腸癌多學科協作組首席專家、復旦大學大腸癌診治中心主任、上海市抗癌協會大腸癌專業委員會主任委員、中國抗癌協會大腸癌專業委員會前主任委員、美國臨床腫瘤指南(NCCN)中國版專家委員會委員、NCCN大腸癌臨床實踐指南(中國版)外科執筆人、主要從事結直腸癌基礎和臨床研究,尤其擅長于大腸癌的手術治療,是中國著名的大腸癌專家。
主編《結直腸肛門腫瘤》(北京大學出版社,2005)及《循證結直腸肛管腫瘤學》(上海科學技術出版社2015)。主持國家自然科學基金課題、國家863及973、復旦211等重大科研課題,累計經費4200余萬。
近5年發表醫學論文90余篇,其中SCI 70余篇。2012獲得上海市科學技術及教育部科技進步二等獎,2018獲上海預防醫學會科學技術二等獎,2019獲第三屆國之名醫盛典-卓越建樹獎和科教資訊一等獎。
研究領域:
1、大腸癌、胃癌、軟組織腹膜后腫瘤、惡性黑色素瘤等腹部腫瘤的手術治療;
2、局部晚期大腸癌及復發轉移性大腸癌的綜合治療;
3、大腸癌的早期篩查、分子生物標志物及復發轉移機制研究;
4、大腸癌類器官平臺建設與轉化治療。
研究團隊:
自2005年來擔任復旦大學大腸癌中心主委、腫瘤醫院大腸癌多學科協作組首席科學家,對大腸癌診治方面的各種治療方式、綜合治療、個體化治療有較深的理解,形成了國內最好的大腸癌MDT隊伍,團隊包括大腸外科、放療科、腫瘤內科、病理科、放射診斷、內鏡科、肝外科、介入科及中醫科,積極推動了國內大腸癌的規范性多學科綜合治療的發展。
代表性論著:
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Li Q#, Wei
P#, Wu J, Zhang M, Li G, Li Y, Xu Y, Li X, Xie D, Cai S*,
Xie K*, Li D*. The FOXC1/FBP1 signaling
axis promotes colorectal cancer proliferation by enhancing the Warburg effect. Oncogene, 2019Jan; 38(4):483-496.
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Hu X#, Li
YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Adjuvant Chemotherapy
Seemed Not to Have Survival Benefit in Rectal Cancer Patients with ypTis-2N0
After Preoperative Radiotherapy and Surgery from a Population-Based Propensity
Score Analysis. Oncologist, 2019 Jun; 24(6):803-811.
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Li Y#,
Wang R#, Huang D#, Ma X, Mo S, Guo Q, Fu G, Li Y, Xu X,
Hu X, Zhou Y, Deng Y, Zhang L, Chen H, Gao J, Zhang Z, Cai S*,
Hua G*, Peng J*. A novel human colon
signet-ring cell carcinoma organoid line: establishment, characterization and
application. Carcinogenesis, 2019 Nov 19.
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Zhang S#,
Yang Y, Weng W, Guo B, Cai G, Ma Y, Cai S*. Fusobacterium
nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3
expression in colorectal cancer. J Exp Clin Cancer Res, 2019 Jan 10; 38(1):14.
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Hu X#, Li
YQ, Ma XJ, Zhang L, Cai SJ*, Peng JJ*. A
Risk Signature With Inflammatory and T Immune Cells Infiltration in Colorectal
Cancer Predicting Distant Metastases and Efficiency of Chemotherapy. Front
Oncol, 2019 Aug 13; 9:704.
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Feng Y#,
Li Y, Huang D, Cai S*, Peng J*. HER2 as a
potential biomarker guiding adjuvant chemotherapy in stage II colorectal
cancer. Eur J Surg Oncol, 2019 Feb; 45(2):167-173.
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Hu X#, Li
YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Osteoglycin (OGN)
reverses epithelial to mesenchymal transition and invasiveness in colorectal
cancer via EGFR/Akt pathway. J Exp Clin Cancer Res, 2018 Mar 2; 37(1):41.
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Li Q#, Li
Y#, Li J, Ma Y, Dai W, Mo S, Xu Y, Li X*, Cai S*.
FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1alpha/CEACAM5
functional axis. Int J Biol Sci, 2018 May 12; 14(7):726-735.
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Hu X#, Li
YQ, Li QG, Ma YL, Peng JJ*, Cai SJ*.
Baseline Peripheral Blood Leukocytosis Is Negatively Correlated With T-Cell
Infiltration Predicting Worse Outcome in Colorectal Cancers. Front
Immunol, 2018 Oct 12; 9:2354.
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Hu X#, Li
YQ, Li QG, Ma YL, Peng JJ*, Cai SJ*. ITGAE
Defines CD8+ Tumor-Infiltrating Lymphocytes Predicting a better Prognostic
Survival in Colorectal Cancer. EBioMedicine, 2018 Sep;
35:178-188.
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Hu X#, Li
YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Osteoglycin-induced VEGF
Inhibition Enhances T Lymphocytes Infiltrating in Colorectal Cancer. EBioMedicine,
2018 Aug;
34:35-45.
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Li Q#, Dai
W#, Jia H#, Li Y, Xu Y, Li X*, Cai G*, Cai S*. Prognostic Impact of Hypochloremia in Patients With
Stage I to III Colorectal Cancer After Radical Resection. Dis Colon
Rectum, 2018 Nov; 61(11):1273-1280.
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Li Y#,
Feng Y#, Dai W, Li Q, Cai S*, Peng J*.
Prognostic Effect of Tumor Sidedness in Colorectal Cancer: A SEER-Based
Analysis. Clin Colorectal Cancer, 2019 Mar; 18(1):e104-e116.
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Yang Y#,
Weng W#, Peng J#, Hong L#, Yang L, Toiyama Y,
Gao R, Liu M, Yin M, Pan C, Li H, Guo B, Zhu Q, Wei Q, Moyer MP, Wang P, Cai
S*, Goel A*, Qin H*, Ma Y*.
Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and
Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to
Nuclear Factor-kappaB, and Up-regulating Expression of MicroRNA-21. Gastroenterology, 2017 Mar;
152(4):851-866.
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Shi D#, Liang
L#, Zheng H, Cai G, Li X, Xu Y*, Cai S*.
Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion in
colorectal cancer. Biomed Pharmacother, 2017 Jan; 85:355-361.
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Li Y#,
Liang L#, Dai W, Cai G, Xu Y, Li X, Li Q*, Cai
S*. Prognostic impact of programed cell death-1 (PD-1) and
PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating
lymphocytes in colorectal cancer. Mol Cancer, 2016 Aug 24; 15(1):55.
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Wang S#,
Zhang Q#, Yang P, Yu X, Huang LY, Shen S*, Cai
S*. Manganese Oxide-Coated Carbon Nanotubes As Dual-Modality
Lymph Mapping Agents for Photothermal Therapy of Tumor Metastasis. ACS Applied Materials &
Interfaces, 2016 Feb 17; 8(6):3736-43.
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Li Y#, Jia
H#, Yu W, Xu Y, Li X, Li Q*, Cai S*.
Nomograms for predicting prognostic value of inflammatory biomarkers in
colorectal cancer patients after radical resection. Int J Cancer,
2016 Jul 1; 139(1):220-31.
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Li Q#, Wei
P#, Huang B#, Xu Y, Li X, Li Y, Cai S*,
Li D*. MAEL expression links epithelial-mesenchymal
transition and stem cell properties in colorectal cancer. Int J Cancer, 2016;
139:2502-11.
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Li Q#, Qin
Y#, Wei P, Lian P, Li Y, Xu Y, Li X, Li D*, Cai
S*. Gas1 Inhibits Metastatic and Metabolic Phenotypes in
Colorectal Carcinoma. Mol Cancer Res, 2016 Sep; 14(9):830-40.
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Li X#,
Liang L#, Huang L, Ma X, Li D, Cai S*. High
expression of protein phosphatase 4 is associated with the aggressive malignant
behavior of colorectal carcinoma. Mol Cancer, 2015 Apr 28; 14:95.
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Li Q#,
Meng X#, Liang L, Xu Y, Cai G*, Cai S*.
High preoperative serum globulin in rectal cancer treated with neoadjunctive
chemoradiation therapy is a risk factor for poor outcome. Am J Cancer
Res,
2015 Aug 15; 5(9):2856-64.
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Li Q#, Wu
J#, Wei P, Xu Y, Zhuo C, Wang Y, Li D, Cai S*.
Overexpression of forkhead Box C2 promotes tumor metastasis and indicates poor
prognosis in colon cancer via regulating epithelial-mesenchymal transition. Am J
Cancer Res, 2015 May 15; 5(6):2022-34.
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Zhuo C#,
Li Z, Xu Y, Wang Y, Li Q, Peng J, Zheng H, Wu P, Li B*, Cai
S*. Higher FOXP3-TSDR demethylation rates in adjacent normal
tissues in patients with colon cancer were associated with worse survival. Molecular Cancer, 2014 Jun 18; 13:153.
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Xu Y#, Xu
Q#, Yang L, Ye X, Liu F, Wu F, Ni S, Tan C, Cai G, Meng X, Cai S*,
Du X*. Identification and validation of a blood-based 18-gene
expression signature in colorectal cancer. Clin Cancer Res, 2013 Jun 1; 19(11):3039-49.
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Peng J#,
Chen W, Venook AP, Sheng W, Xu Y, Guan Z, Cai G, Cai S*.
Long-term outcome of early-stage rectal cancer undergoing standard resection
and local excision. Clin Colorectal Cancer , 2011 Mar 1; 10(1):37-41.
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