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2000年畢業于佳木斯大學臨床醫學專業獲得臨床學士學位，2005年畢業于復旦大學動物學專業獲得理學碩士學位，2011年畢業于上海交通大學腫瘤學專業獲得腫瘤學博士學位。2005年7月-2018年5月就職于上海市腫瘤研究所，2018年6月起就職于復旦大學附屬腫瘤醫院，擔任腫瘤研究所實驗動物平臺主管。目前任上海市實驗動物學會理事，上海市實驗動物學會資源與設施專業委員會副主任委員，擔任《實驗動物與比較醫學》編委。工作以來主要從事腫瘤高轉移動物模型篩選及建立、腫瘤轉移相關分子機制等研究工作。以第一作者、通訊作者發表論文10余篇，參與發表論文20余篇；以第一責任人申請國家自然科學基金2項、上海市科委“創新行動計劃”等課題8項，總經費約300萬元，作為骨干參與國家“973”、國家十二五科技重大公關等課題研究；以第一發明人申請國家發明專利4項，參與申請5項，其中2項獲得專利授權。參編專業書籍2本，獲得上海醫學科技獎三等獎1項。
研究領域：
腫瘤轉移的分子機制研究及抗腫瘤轉移的治療研究：
1. 腫瘤轉移動物模型的篩選及建立
2. 基于動物模型的抗腫瘤轉移治療研究
3. 腫瘤轉移的分子機制研究
代表性論著：
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Li Jing#,
Cheng Dongdong#, Zhu Miaoxin, Yu Huajian, Pan Zhen, Liu Lei, Geng
Qin, Pan Hongyu, Yan Mingxia*,
Yao Ming*.OTUB2 stabilizes U2AF2 to promote the Warburg effect and
tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer. Theranostics,
2019; 9(1):179–195.
metastasis of human
non-small-cell lung cancer by downregulating the
ERBB4/PIK3R3/mTOR/S6K2signaling pathway. Oncogene, 2015; 34:413-423.
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Chu D#, Li J#,
Lin H, Zhang X, Pan H, Liu L, Yu T, Yan
M*, Yao M*.Quantitative proteomic analysis of the miR-148a-associated mechanisms of
metastasis in non-small cell lung cancer.Oncol Lett., 2018;
15(6):9941–9952.
-
Hechun Lin#,
Xiao Zhang#, Li Liao, Tao Yu, Jing Li, Hongyu Pan, Lei Liu, Hanwei
Kong, Lei Sun, Mingxia Yan*,
Ming Yao*. CPNE3 promotes migration and invasion in non-small
cell lung cancer by interacting with RACK1 via FAK signaling activation. J Cancer., 2018; 9(22):4215–4222.
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Dandan Chu#,
Jing Li#, Hechun Lin, Xiao Zhang, Hongyu Pan, Lei Liu, Tao Yu, Mingxia Yan*, Ming Yao*. Quantitative proteomic analysis of the
miR-148a-associated mechanisms of metastasis in non-small cell lung cancer.OncolLett., 2018; 15(6):9941–9952.
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Yu T#, Zhao Y#,
Hu Z, Li J, Chu D, Zhang J, Li Z, Chen B, Zhang X, Pan H, Li S, Lin H, Liu L,
Yan M, He X*, Yao M*.MetaLnc9
Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway.Cancer
Res., 2017; 77(21):5782-5794.
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Wei Deng#, Mingxia Yan#, Tao Yu, Haiyan
G, Hechun Lin, JingLi, Ying Liu, Qin Geng, Miaoxin Zhu, Lei Liu, Xianghuo He*,
Ming Yao*. Quantitative proteomic analysis of the
metastasis-inhibitory mechanism of miR-193a-3pin non-small cell lung cancer.Cell
PhysiolBiochem., 2015; 35:1677-1688.
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Cui YQ#,
Geng Q, Yu T, Zhang FL, Lin HC, Li J, Zhu MX, Liu L, Yao M*, Yan MX*. Establishment of a
highly metastatic model with a newly isolated lung adenocarcinoma cell line.Int
JOncol., 2015; 47(3):927-940.
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Jing Li#,
Tao Yu#, Jun Cao, Lei Liu, Ying Liu, Han-Wei Kong, Miao-Xin Zhu,
He-Chun Lin, Dan-danChu, Ming Yao*, Ming-Xia Yan*.MicroRNA-148a Suppresses Invasion and
Metastasis of Human Non-Small-Cell Lung Cancer. Cell PhysiolBiochem.,
2015; 37:1847-1856.
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Mingxia Yan#, Hong Li, Miaoxin Zhu, Fangyu Zhao, Lixing
Zhang, Taoyang Chen, Guoping Jiang, HaiyangXie, Ying Cui, Ming Yao, Jinjun Li*.GProtein-Coupled
Receptor 87 (GPR87) promotes the growth and metastasis of CD133+ cancer stem-like cells in hepatocellular carcinoma. PLoS ONE, 2013; 8(4):
e61056.
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Mingxia Yan#, Hong Li, Fangyu Zhao, Lixing Zhang, Chao
Ge, Ming Yao, Jinjun Li*.Establishment of NOD/SCID mouse models of
human hepatocellular carcinoma via subcutaneous transplantation of
histologically intact tumor tissue. Chin J Cancer Res., 2013; 25(3):
289-298.
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Tao Yu#,
Jing Li, Mingxia Yan, Lei Liu, Hechun Lin, Fangyu Zhao, Lei Sun, Yu Zhang,
Yongqi Cui, Fanglin Zhang, Jinjun Li, Xianghuo He, Ming Yao*.
MicroRNA-193a-3p and -5p suppress the
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